A perforation duodenal ulcer occurs when an area of erosion eats right through the gut wall in the part of the digestive system leading from the stomach, knows as the duodenum .the life-threatening condition known as peritonitis may follow, where inflammation and infection spread rapidly into the abdominal cavity affecting the entire major organ. Ulcer usually has a history of indigestion perhaps involving reflux , where stomach acid passes up into the throat .with a perforated duodenal ulcer there may be a sudden pain in the centre of the chest just below the breast bone, become a more generalised abdominal pain and emergency surgery is generally required to repair the gut. Objective: Study of parental antibiotics used in post-operative perforation duodenal ulcer in a surgery department Material method: Prospective observation study, all the patients admitted in gynecology ward in RMMCH during in 4 month study period from October 2016 to January 2017 who has compliance with inclusion and exclusion criteria. Results: The total number of 40 patients. The male (85%) patients are mostly affected when compared to female patients (15%) with duodenal ulcer. Among the study population, more patients with duodenal perforation were the under age group of 51-61 years. Followed by the elderly patient with age group above sixty. The majority of the parenteral antibiotics mostly prescribed in metronidazole >amikacin >cefotaxim > ciprofloxacin > gentamycin > cefixime.