Chronic Supperative otitis media a commonly encountered clinical condition in ENT causing hearing impairment disability social stigma and poor school performance. The incidence of chronic otitis media (COM) appears to depend on socio-economic factors. The present study compared the efficacy of oral, topical and combined oral plus topical ofloxacin to make discharging ear dry in patients suffering from chronic otitis media (active mucosal type). A total of 150 patients suffering from chronic otitis media selected for the study. Patients with uncomplicated discharging Com who were eligible for the study were explained about their condition and a written consent was obtained for the study baseline audiometry was done in all patients participating in the study. The patients were then divided into 3 groups by random sampling method. Group A - only topical antibiotic Group B - only Oral antibiotic Group C - Combined oral plus topical antibiotic In our study, only topical ofloxacin is better and cost-effective than only oral and combined oral plus topical ofloxacin in controlling discharge in COM. cases. We can safely prescribe only topical ofloxacin drops as empirical therapy to control symptoms of com which is cost effective in comparison to oral ofloxacin and devoid of systemic side effects. In the absence of systemic infection, topical ofloxacin alone constitute first-line treatment for most patients with chronic otitis media (active mucosal type) No evidence suggests that systemic ofloxacin alone or in combination with topical preparations improve treatment outcomes compared with topical ofloxacin alone