To report the trend in prescription and what are the drug drug interactions observed in variety of prescription get from a hospital at kamptee in February 2017. Methods: We analysed the prescriptions which are collected by us and we check the drug trend, drug drug interactions and essential drug is prescribed by physician or not. Results: Total 45 no. of prescriptions are analysed by us from that most of the prescriptions contains antibiotics and NSAIDs used with PPI. There are many drug drug interactions observed of mild and moderate type and many of the drugs are not of essential drugs that are prescribed by the physician. Conclusion: Antibiotics, NSAIDs and PPI are most widely used to prescribed by the physician. Only 5-6% drugs are prescribed from the essential drug list and 40-45% of prescriptions having drug drug interactions.