This paper is published in Volume 3, Issue 2, 2018
Area
Pharmacology
Author
Pooja Belapurkar
Co-authors
Sonal More, Gaurav Patil, Mahalaxmi Mohan
Org/Univ
Mahatma Gandhi Vidyamandir's Pharmacy College, Nashik, Maharashtra, India
Pub. Date
28 February, 2018
Paper ID
V3I2-1239
Publisher
Keywords
Diabetic Neuropathy, Hyperglycemia, Type 1 Diabetes, Type 2 Diabetes, Pain.

Citationsacebook

IEEE
Pooja Belapurkar, Sonal More, Gaurav Patil, Mahalaxmi Mohan. A Review on Diabetic Neuropathy, International Journal of Advance Research, Ideas and Innovations in Technology, www.IJARnD.com.

APA
Pooja Belapurkar, Sonal More, Gaurav Patil, Mahalaxmi Mohan (2018). A Review on Diabetic Neuropathy. International Journal of Advance Research, Ideas and Innovations in Technology, 3(2) www.IJARnD.com.

MLA
Pooja Belapurkar, Sonal More, Gaurav Patil, Mahalaxmi Mohan. "A Review on Diabetic Neuropathy." International Journal of Advance Research, Ideas and Innovations in Technology 3.2 (2018). www.IJARnD.com.

Abstract

Diabetic neuropathy (DN) is the most common and multifactor complication of diabetes mellitus. It is late finding in type I diabetes and can be an early finding in type II diabetes. It is characterized by hyper responsiveness to pain typically originating in the extremities, progressive loss of neuronal function. The exact etiopathogenesis of diabetic neuropathy is dependent on many factors such as hyperglycemia, neuronal loss, alteration in neurotransmitters and growth factors. Other mechanism include, insulin deficiency, oxidative stress, nitrosative stress, ischemia, osmolytic accumulation, neurotropic factor deficiency, autoimmune nerve destruction, alteration in cellular signaling pathways and gene expression of proteins. The main risk factor for diabetic neuropathy is hyperglycemia. Good control of hyperglycemia, blood pressure and dyslipidemia is important for prevention and reducing progression of neuropathy. Although current treatment focusses on pain management, attention should be paid to potential risk factors for neuropathy. For eg. glycemic control, hyperlipidemia, and hypertension should be managed with diet, exercise and medication.
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